NIPT Advanced
A private nipt advanced taken by an experienced phlebotomist at our Widnes or Crewe clinic and analysed by an accredited pathology laboratory. This test measures 9 biomarkers, listed in full below.
- Results turnaround
- 5 working days from the sample reaching the laboratory
- Sample type
- 10ml venous blood sample from mum's arm, from 10 weeks of pregnancy
- Biomarkers measured
- 9 included
How noninvasive prenatal testing (NIPT) works
NIPT analyses the mix of maternal and fetal DNA naturally present in your bloodstream, screening for chromosomal conditions without any risk to your pregnancy.
- 1
Fetal DNA circulates in your bloodstream
Cell-free fetal DNA from the placenta joins your own DNA in the maternal circulation from early in pregnancy.
- 2
A single venous blood draw
No amniocentesis, no needle near the baby — just a standard blood sample taken by a qualified phlebotomist.
- 3
Chromosome screening in the laboratory
The lab separates and sequences the fetal DNA to screen for chromosomal conditions and, if you wish, reports fetal sex.
What this test measures
Every individual marker included in the nipt advanced, grouped by laboratory panel.
Common trisomies
- Down's syndrome (Trisomy 21)
- Edward's syndrome (Trisomy 18)
- Patau's syndrome (Trisomy 13)
Fetal sex
- Fetal sex — male (XY) / female (XX), optional
Microdeletions
- High-demand 6 microdeletion syndromes
Sex chromosome anomalies
- Jacob's syndrome (XYY)
- Klinefelter's syndrome (XXY)
- Triple X syndrome (XXX)
- Turner syndrome (XO)
Compare the three NIPT options
All three Concepto NIPT tests use the same simple 10ml blood sample from mum's arm, from 10 weeks of pregnancy. They differ only in how much they screen for.
| Screened for | NIPT Standard | NIPT Advance | NIPT Absolute |
|---|---|---|---|
| Common trisomies | |||
| Down's syndrome (Trisomy 21) | |||
| Edward's syndrome (Trisomy 18) | |||
| Patau's syndrome (Trisomy 13) | |||
| Gender — male (XY) / female (XX), optional | |||
| Sex chromosome anomalies | |||
| Turner syndrome (XO) | |||
| Klinefelter's syndrome (XXY) | |||
| Jacob's syndrome (XYY) | |||
| Triple X syndrome (XXX) | |||
| Microdeletions | |||
| High-demand 6 microdeletions | |||
| High-demand 92 microdeletions | |||
Proven accuracy
Concepto NIPT uses massively parallel whole-genome sequencing, validated on a study population of 146,958 pregnancies. Resample rate 2.18%, no-call rate 0.069%.
| Condition | Sensitivity | Specificity |
|---|---|---|
| Trisomy 21 | 99.17% | 99.95% |
| Trisomy 18 | 98.24% | 99.95% |
| Trisomy 13 | >99.9% | 99.96% |
| Copy number variants (≥10 Mb) | >99.9% | 99.97% |
| Copy number variants (<10 Mb) | >99.9% | 99.86% |
| Fetal sex | 99.53% | 99.20% |
| Sex chromosome aneuploidies (XO, XXX, XXY, XYY) | >99.9% | 99.6% |
Who this test is for
- Any pregnancy from 10 weeks onwards, regardless of age or family history
- Twin pregnancies (basic trisomies only)
- IVF pregnancies and pregnancies using a donated egg
- Where invasive testing such as amniocentesis is not advisable
- Reassurance after a previous screening result or a previous chromosomal condition
When we can't test
- Gestational age must be at least 10 weeks at the time of the blood draw
- Triplet pregnancies cannot be tested
- Vanishing twin: at least 8 weeks must have passed since developmental cessation, which must have occurred before week 8
- Heparin therapy: leave at least a 24-hour gap before the sample is taken
- Cellular immunotherapy or human serum albumin therapy: at least a 4-week gap
- Blood transfusion: at least a 1-year gap
- Not suitable after stem cell therapy, organ transplant, an active tumour, or with an abnormal maternal karyotype
If you're unsure whether any of these apply to you, call us before booking and we'll talk it through.
About this test
Concepto NIPT Advance covers everything in NIPT Standard — the three common trisomies, the four sex chromosome anomalies and optional gender detection — and adds screening for the six high-demand microdeletion syndromes. Available from 10 weeks of pregnancy from a single 10ml blood sample.
How your appointment works
- 1
Book online and choose Widnes or Crewe — most people are seen within a few days.
- 2
Arrive a few minutes early; your appointment usually takes 10–15 minutes.
- 3
Your sample is labelled in front of you and sent to the laboratory the same day.
- 4
Your results arrive securely by email, typically 5 working days from the sample reaching the laboratory.
Frequently asked questions
People also consider
All testsNIPT Absolute
- 10 biomarkers measured
- 5 working days from the sample reaching the laboratory
NIPT Standard
- 8 biomarkers measured
- 5 working days from the sample reaching the laboratory
Rubella IgG antibody
- 1 biomarker measured
- Same Day
AMH Blood Test
- 1 biomarker measured
- Typically 2–5 working days
Blue or Pink Gender Blood Test
- 1 biomarker measured
- 1–3 working days
Female Hormone and Fertility Blood Test
- 7 biomarkers measured
- Typically 2–5 working days